Abstract
Acute graft-versus-host disease (aGVHD) is a significant complication for patients who receive allogeneic stem cell transplantation. Patients whose aGVHD is refractory to corticosteroids face additional complications. This article provides foundational knowledge on steroid-refractory (SR) aGVHD, current treatment options, and related supportive care. Therapies for patients with SR aGVHD are summarized, along with supportive care recommendations and a review of related nursing considerations. Current treatment and research on SR aGVHD offer opportunities for improved clinical outcomes for these patients. Nursing knowledge of the pathophysiology, treatment, and supportive care for patients with SR aGVHD is integral to the provision of optimal nursing care for a complex population of patients.
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