Abstract

The care for a patient with ulcerative colitis (UC) remains challenging despite the fact that morbidity and mortality rates have been considerably reduced during the last 30 years. The traditional management with intravenous corticosteroids was modified by the introduction of ciclosporin and infliximab. In this review, we focus on the treatment of patients with moderate to severe UC. Four typical clinical scenarios are defined and discussed in detail. The treatment recommendations are based on current literature, published guidelines and reviews, and were discussed at a consensus meeting of Swiss experts in the field. Comprehensive treatment algorithms were developed, aimed for daily clinical practice.

Highlights

  • Ulcerative colitis (UC) is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, and, besides Crohn’s disease (CD), it is one of the two major forms of inflammatory bowel disease (IBD) [1]

  • The traditional management with intravenous corticosteroids was modified by the introduction of ciclosporin and infliximab

  • We focus on the treatment of patients with moderate to severe ulcerative colitis (UC)

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Summary

Practical consensus recommendations

1 and the following experts (in alphabetical order): C.

Summary
Introduction
Review article
Patient characteristics
Findings
Conclusions

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