Abstract
Methods A multicenter cross-sectional study involving seven referral centers from three cities of Argentina was undertaken. Patients with a diagnosis of ulcerative colitis (UC), Crohn's disease (CD), or indeterminate colitis (IBDU/IC) were invited to answer an anonymous survey, which included a 5-point Likert scale to evaluate adherence to therapies. Independent variables associated with inadequate adherence were evaluated. Results Overall, 447 UC/IBDU and 135 CD patients were enrolled. Median age was 37 years (range 21-72); 39.8% were male; median time from diagnosis was 6 years (0.5-35). 91.4% were under treatment with at least one oral medication; 50.3% of patients reported inadequate adherence to oral medications. Patients with UC/IBDU had a lower risk of inadequate adherence when compared to patients with CD (OR 0.57 (0.37-0.87)). 21.8% reported inadequate adherence to biologics; subcutaneous administration was significantly associated with inadequate adherence to biologics (OR 4.8 (1.57-14.66)). Conclusion Inadequate treatment adherence is common among patients with IBD, and potentially modifiable factors were identified.
Highlights
IntroductionMedical treatment consists in the administration of medications that induce a modulation of the immune system at the gastrointestinal level, halting inflammatory activity in inflammatory bowel disease (IBD) patients [3]
Inflammatory bowel disease (IBD) comprises mainly two chronic, immune-mediated, and potentially disabling conditions: ulcerative colitis (UC) and Crohn’s disease (CD) [1, 2].Currently, medical treatment consists in the administration of medications that induce a modulation of the immune system at the gastrointestinal level, halting inflammatory activity in inflammatory bowel disease (IBD) patients [3]
Previous studies have described the prevalence of inadequate adherence in IBD patients, as well as factors associated with this behavior [11,12,13,14,15,16,17,18]
Summary
Medical treatment consists in the administration of medications that induce a modulation of the immune system at the gastrointestinal level, halting inflammatory activity in IBD patients [3] Given that these are chronic diseases characterized by periods of flare and remission, mainte-. Previous studies have described the prevalence of inadequate adherence in IBD patients, as well as factors associated with this behavior [11,12,13,14,15,16,17,18]. The aim of this study was to determine inadequate adherence to oral and parenteral therapies in patients with IBD from Argentina and to identify factors associated with it. Inadequate treatment adherence is common among patients with IBD, and potentially modifiable factors were identified
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