Abstract
A single drug treats type-1 diabetes in mice by dampening inflammation and enhancing insulin production.
Highlights
Image The drug I-BET151 acts on β cells and macrophages in the islets of the pancreas to treat type-1 diabetes in mice (Image credit: James F Mohan)
Type-1 diabetes is an autoimmune disease in which the body's own immune cells attack islet β cells, the cells in the pancreas that produce and release the hormone insulin
The remarkable efficacy of I-BET151 for the treatment of insulitis is attributed to its dual effects on pancreatic macrophages and β cells
Summary
Image The drug I-BET151 acts on β cells (red) and macrophages (green) in the islets of the pancreas to treat type-1 diabetes in mice (Image credit: James F Mohan) Type-1 diabetes is an autoimmune disease in which the body's own immune cells attack islet β cells, the cells in the pancreas that produce and release the hormone insulin. Chronic inflammation in the islets (called insulitis) eventually leads to the complete destruction of the β cells, resulting in an insulin deficiency that causes type-1 diabetes.
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