Abstract
Treating scleroderma lung disease with B cell depletion
Highlights
Systemic Sclerosis is a chronic, autoimmune disease affecting the skin and internal organs
Screening is based upon chest high resolution computed tomography images (HRCT) displaying 2 patterns: predominantly non-specific interstitial pneumonia (NSIP) and less frequently usual interstitial pneumonia (UIP)
A broad range of patients with non-responding resistant Interstitial lung disease (ILD) was recruited to receive different therapies and lung function was evaluated in 6 months
Summary
Systemic Sclerosis is a chronic, autoimmune disease affecting the skin and internal organs. Boonstra M et al [25] studied patients with early SSc. Half of them were treated with RTX 1000 mg biweekly (“RA scheme”) and the rest of them with placebo treatment over a period of 2 years. The study disclosed that after 2 years FVC and the extent of lung involvement slightly improved with RTX, but this difference was insignificant when compared to the placebo group.
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