Abstract
Treating fatty liver and insulin resistance
Highlights
Type 2 diabetes (T2D) is predicted to affect one in three Americans by the year 2050 and is a leading cause of blindness, end stage renal failure and loss of limb with associated costs exceeding $180 billion/year
Evidence in support of the key role of ectopic lipid in the pathogenesis of hepatic insulin resistance and T2D in humans comes from studies where we (Petersen et al, Diabetes 2005; 54:603-608) and others (Lim et al, Diabetologia 2011, 54:2506-2514) have shown that modest weight loss (~8 kg) resulted in large (~80%) reductions in liver triglyceride content, which were associated with normalization of fasting plasma glucose concentrations, hepatic glucose production and hepatic insulin sensitivity
Given the markedly increased therapeutic window for DNP-methyl ether (DNPME) versus DNP we examined whether DNPME would reverse insulin resistance, hepatic steatosis and diabetes in the rat
Summary
Type 2 diabetes (T2D) is predicted to affect one in three Americans by the year 2050 and is a leading cause of blindness, end stage renal failure and loss of limb with associated costs exceeding $180 billion/year. Evidence in support of the key role of ectopic lipid in the pathogenesis of hepatic insulin resistance and T2D in humans comes from studies where we (Petersen et al, Diabetes 2005; 54:603-608) and others (Lim et al, Diabetologia 2011, 54:2506-2514) have shown that modest weight loss (~8 kg) resulted in large (~80%) reductions in liver triglyceride content, which were associated with normalization of fasting plasma glucose concentrations, hepatic glucose production and hepatic insulin sensitivity.
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