Abstract
Although fatigue is widely accepted to be one of the most common and disabling symptoms of multiple sclerosis (MS), it remains difficult to define and quantify, and its cause remains poorly understood.1 In general, management of fatigue begins with identification and amelioration of other factors contributing to it, such as depression, pain, sleep disorders, and comorbid medical conditions. Nonpharmacologic treatments, including graded exercise training,2 energy management strategies,3 and cooling therapy,4 have been tried, but evidence supporting their effectiveness is limited. Several pharmacologic treatments have been tried as well. Two studies reported in this issue of Neurology provide further information on the difficulties of treating this distressing MS symptom, one suggesting that a medication commonly prescribed for fatigue is ineffective,5 the other suggesting that an even more commonly used medication may have some benefit.6 The only treatments previously demonstrated to have an effect on fatigue in placebo-controlled clinical trials are …
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
