TREASURE: Text Mining Algorithm Based on Affinity Analysis and Set Intersection to Find the Action of Tuberculosis Drugs against Other Pathogens

Abstract

Tuberculosis (TB) is one of the top causes of death in the world. Though TB is known as the world’s most infectious killer, it can be treated with a combination of TB drugs. Some of these drugs can be active against other infective agents, in addition to TB. We propose a framework called TREASURE (Text mining algoRithm basEd on Affinity analysis and Set intersection to find the action of tUberculosis dRugs against other pathogEns), which particularly focuses on the extraction of various drug–pathogen relationships in eight different TB drugs, namely pyrazinamide, moxifloxacin, ethambutol, isoniazid, rifampicin, linezolid, streptomycin and amikacin. More than 1500 research papers from PubMed are collected for each drug. The data collected for this purpose are first preprocessed, and various relation records are generated for each drug using affinity analysis. These records are then filtered based on the maximum co-occurrence value and set intersection property to obtain the required inferences. The inferences produced by this framework can help the medical researchers in finding cures for other bacterial diseases. Additionally, the analysis presented in this model can be utilized by the medical experts in their disease and drug experiments.