Trazodone by epigenetic mechanism can reverse the post finasteride syndrome

Abstract

The action mechanism of finasteride as inhibitor of the 5alpha-reductase enzyme in the brain could cause an epigenetic change imbalance in the messenger RNA of androgen receptor. The decrease of dihydrotestosterone (DHT) followed by an increase of free testosterone in the brain could in theory cause an imbalance in acetylation and methylation of histones in neurons. So, the post finasteride syndrome would be caused by an epigenetic change in androgen receptors of neurons circuits. Thus, the alpha-adrenergic antagonist properties of trazodone, for example cause priapism, and could change the epigenetic expression of androgen receptors in neuronal circuits responsible for erection and libido. Therefore, through this mechanism, the trazodone could reverse the effect of finasteride on the brain.