Abstract
✓ Children with rare coagulation disorders are at high risk from intracranial bleeding with even minor head injury. Treatment by transfusion of fresh frozen plasma is limited because of the large volumes required for restoring the missing coagulation factor. Furthermore, even when concentrates of such a factor are available, their use may prove ineffective due to circulating specific antibodies. Three patients with rare coagulation disorders are presented who suffered head injury complicated by intracranial hemorrhage.
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