Abstract

Traumatic brain injury in elderly people imposes an increasing burden on Western society. The outcome is far worse compared with younger victims, which seems logical at first sight. However, specific pathophysiological processes that are responsible for these poorer outcomes largely remain unclear, which makes it difficult to assess individual prognosis. This review summarizes recent specific literature in an attempt to list factors that characterize geriatric traumatic brain injury as different to traumatic brain injury in younger people, and to identify factors that are potential candidates to explain the poorer outcome in this age category. Reduced cardiovascular and endocrinological resilience seem to be potential explanatory variables, compromising cerebral autoregulation and oxidative glucose metabolism, respectively.

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