Abstract
Introduction: Sarcoidosis is a complex systemic granulomatous disease of unknown etiology, characterized by the formation of non-caseous granulomas. It has a biphasic age pattern, with higher incidence in young adults as well as in older people. Trastuzumab is a monoclonal antibody that inhibits the Human Epidermal Growth Factor Receptor (HER2) and there are few reports in the literature concerning sarcoidosis or sarcoidosis-like reactions induced by cancer immunotherapy. Case report: We reported a peculiar association between sarcoidosis and trastuzumab immunotherapy in a 38-year-old woman with breast cancer. Multiple well-defined lung nodules in a perilymphatic distribution were seen in association with opacities that tended to merge to form nodular images with irregular outlines, the so-called galaxy sign, in the posterior part of the upper left lobe. Conclusion: Herein, we also briefly review the role of neoplasic factors in sarcoidosis and immunopathological triggers to the development of granulomas in patients under trastuzumab therapy. Keywords: sarcoidosis; breast cancer; neoplasis; monoclonal antibody; trastuzumab
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