Abstract
OPINION article Front. Physiol., 29 April 2020 | https://doi.org/10.3389/fphys.2020.00340
Highlights
Reviewed by: Sreedhar Subbarao Amere, Centre for Cellular & Molecular Biology (CCMB), India Julia C
Tumor necrosis factor receptor-associated protein 1 (TRAP1), known as heat shock protein 75 (Hsp75), is the mitochondrial member of the Hsp90 family of molecular chaperones, which acts as a key regulator of mitochondrial homeostasis and bioenergetics (Hoter et al, 2018)
S-nitrosoglutathione reductase (GSNOR) is the prototype of this class of enzymes. It contributes to regulate the levels of S-nitrosylated proteins (PSNOs) (Rizza and Filomeni, 2017); conditions of groups. S-nitrosoglutathione reductase (GSNOR) deficiency are associated with a general increase of PSNOs
Summary
Reviewed by: Sreedhar Subbarao Amere, Centre for Cellular & Molecular Biology (CCMB), India Julia C. TRAP1 is able to rewire metabolism by downregulating mitochondrial oxidative phosphorylation (OXPHOS) and promoting glycolysis, a feature resembling the so-called “Warburg effect” distinctive of cancer cells (Yoshida et al, 2013).
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