Abstract
Transvascular escape rate of albumin (TERa) was measured with 131I-RISA during hepatic vein catheterization in 10 males (age 46-67) with alcohol abuse and biopsy-verified liver cirrhosis. Portal hypertension (mean wedged hepatic vein pressure 26 ± 6.6 (S.D.) mm Hg), and low serum albumin concentration (mean 425 ± 90 (S.D.) μmol/l) were present. Diuretic treatment was given to 9 subjects. TERa (mean 11.4 ± 3.1 (S.D.) per cent/hour) was substantially increased (P < 0.001) compared to normals (Parving & Gyntelberg, 1973). A positive correlation between the post-sinusoidal resistance and TERa (r = 0.91, P <0.02) indicates an elevated splanchnic albumin escape rather than increased systemic transvascular escape. No significant correlation could be demonstrated between TERa and wedged hepatic vein pressure. Negative correlation was demonstrated between TER, and the intravascular mass of albumin (r = −0.69, P <0.05). The total lymph flow, assuming steady state, was estimated as total albumin plasma clearance (pl...
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