Abstract
One approach which can be used to discover the function(s) of the kallikrein-kinin system is to make the assumption that tissue kallikrein can generate lysyl bradykinin (LBK, kallidin) in tissues, where it then acts as local hormone. If this be true then it follows that novel effects of kinin may be discovered in tissues where kallikrein is especially localized. Consideration of these effects may then allow some conclusions to be drawn about the roles of the kallikrein-kinin system in either physiological or pathological states.
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