Abstract
Transport through liquid membranes generated by lecithin, cholesterol and lecithin-cholesterol mixtures has been studied in the presence of prostaglandins. The data indicate that prostaglandins in association with cholesterol may be responsible for the aqueous pores present in the lipid bilayers controlling passive transport through biomembranes. The data further indicate that the presence of cholesterol in each of the two constituent monolayers of the lipid bilayer is essential for pore formation by prostaglandins.
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