Transport of the amino acids, 1-amino cyclopentane-1-carboxylic acid and ε-aminocaproic acid, across intestinal mucosa in vitro

Abstract

Two α-methyl substituted amino acids, 1-amino cyclopentane-1-carboxylic acid (ACPC), and isovaline, are actively transported across everted sacs of small intestine from the rat. ACPC inhibits growth of the Walker rat carcinoma. The antifibrinolytic amino acid, ε-aminocaproic acid (EACA), was not actively transported at therapeutic concentrations. These studies are relevant to the design of pharmacologically active amino acids or their analogues which may be introduced into cells by an active process rather than by passive diffusion.