Abstract

The transport of potassium across the isolated frog gastric mucosa was studied by the chamber method. The net flux of potassium from the nutrient to the secretory phase ( JnsK) did not follow the predictions of simple passive diffusion when the mucosa was incubated with equivalent concentrations of K+ in the secretory and nutrient phases. Furthermore, a net gain in secretory potassium occurs against the electrochemical potential gradient if the mucosa is first incubated with nutrient solutions containing 4 mEq/1. of K+. Neither the loss of K+ from mucosal cells nor solvent drag appears to account for the positive values of JnsK under these circumstances. These data indicate, therefore, that there is a small but significant component of active potassium transport in this preparation.

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