Abstract

The influence of streptolysin O and staphylococcal alpha toxin on the in vitro transport of water and sulfamethoxydiazine from the lumen of rat intestine has been studied. Streptolysin O inhibited the transport of water and sulfamethoxydiazine, when the lysin was applied into the solution circulating in the lumen of intestine and when it was injected intravenously. The staphylococcal toxin had no effect on the transports of water or sulfamethoxydiazine when administered in vitro into the solution in the lumen. In rats intoxicated by previous injection of staphylococcal toxin the transport of water and sulfamethoxydiazine was influenced biphasically. In the first phase the transports were slightly increased, after which inhibition of transport was observed. The dependence of the in vitro water transport on the concentrations of glucose in the solution is described.

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