Abstract
Acid phosphatase accumulates at the severed ends of transected peripheral nerve or spinal cord. We examined the temporal sequence of enzyme accumulation from 1 to 14 days after transecting or applying colchicine to the rat sciatic nerve in order to ascertain whether or not this accumulation is related to axonal transport. Enzyme activity was observed in the proximal and distal stumps by 1 day after transection, and by 1 week activity in the proximal stump exceeded that in the distal stump. In some experiments, colchicine was applied to the nerve proximal to the site of nerve transection. This procedure resulted in an accumulation of acid phosphatase proximal to the site of drug application and not immediately proximal to the site of transection. These results are consistent with the hypothesis that bidirectional transport of acid phosphatase is a normal feature of peripheral nerves.
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