Transport Characteristics of Aquaporins.

Abstract

Aquaporins (AQP) are a class of the integral membrane proteins. The main physiological function of AQPs is to facilitate the water transport across plasma membrane of cells. However, the transport of various kinds of small molecules by AQPs is an interesting topic. Studies using in vitro cell models have found that AQPs mediated transport of small molecules, including glycerol, urea, carbamides, polyols, purines, pyrimidines and monocarboxylates, and gases such as CO2, NO, NH3, H2O2 and O2, although the high intrinsic membrane permeabilities for these gases make aquaporin-facilitated transport not dominant in physiological mechanism. AQPs are also considered to transport silicon, antimonite, arsenite and some ions; however, most data about transport characteristics of AQPs are derived from in vitro experiments. The physiological significance of AQPs that are permeable to various small molecules is necessary to be determined by in vivo experiments. This chapter will provide information about the transport characteristics of AQPs.