Abstract
Background. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists. Methods. We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice. Results. After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. Conclusions. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
Highlights
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease
The cells were strongly positive for CD90, CD29, and CD13 expression and negative for CD34 and CD31 expression, indicating that our isolated and cultured H-umbilical cord MSCs (UC-MSCs) are of high purity
Flow cytometric results showed that the H-UC-MSCs expressed CD90, CD29, and CD13 but did not express CD31 or CD34, indicating that the isolated H-UC-MSCs were of high purity (Figures 1(c)–1(e))
Summary
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. SLE was generally fatal before the advent of immunosuppressive medications Despite these advances in immunosuppressive medical therapies, SLE remains potentially fatal in some patients, in those patients with treatment-refractory disease. Disease severity and organ involvement vary significantly among SLE patients, T and B lymphocyte abnormalities are universal [1,2,3]. Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation. The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice
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