Abstract
Objective: This is an experimental study which aims at developing and evaluating the feasibility of experimental techniques of vascularized and cutaneous abdominal heterotopic heart transplant in mice, creating an instrument of investigation for the effectiveness of prservation solutions, Experimental heterotopic cardiac and cutaneous transplantation in mice
Highlights
Nowadays organ transplantation is the most efficient therapy for patients with end organ failure
Maintenance of allografts require the permanent use of immunosuppressant drugs, which increase the incidence of tumors and opportunist infections, but even so the drugs do not totally impede the rejection process which continues to be the main cause of long-term graft loss
This study aims at developing experimental techniques of skin and vascularized abdominal heterotopic heart transplantations in mice, with the objective of utilizing them as an instrument of study of the immunological mechanisms involved in allorecognition, in the evaluation of new immunosuppressant drugs or biological agents and in the induction of tolerance
Summary
Both techniques are characterized by the easy reproducibility of the experimental models. Resumo Objetivo: Estudo experimental com o objetivo de desenvolver e avaliar a viabilidade das técnicas de transplante experimental cardíaco heterotópico abdominal vascularizado e cutâneo em camundongos, criando um instrumento para. SESTERHEIM, P ET AL - Experimental heterotopic cardiac and cutaneous transplantation in mice. Método: Para este estudo, as técnicas utilizadas foram descritas previamente por Corry et al e Billingham et al. Resultados: O tempo cirúrgico total para a realização dos transplantes cardíacos (n=20) foi, em média, 60,3±6,3 minutos e para os transplantes cutâneos (n=20), 17,75±0,71 minutos. A média de sobrevida dos aloenxertos cutâneos (n=34) e cardíacos (n=24) foi, respectivamente, 7 e 11 dias, enquanto que os isoenxertos sobreviveram por mais de 100 dias
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