Transplantace jater pro akutní selhání jater

Abstract

Summary: Acute liver failure is a rare, highly devastating, potentially reversible condition characterised by the sudden onset of severe liver dysfunction in individuals without pre-existing liver disease and with a poor prognosis. In recent decades, advances in the diagnosis of the disease, a better understanding of its pathophysiology and the development of supportive care have improved the prognosis of patients with acute liver failure. However, despite the success of conservative therapy, urgent liver transplantation remains the only chance of survival for a large proportion of patients with acute liver failure. Early diagnosis of the disease, implementation of supportive care and identification of patients indicated for urgent liver transplantation are essential measures in the management of patients with acute liver failure. Key words: acute liver failure – transplantation – supportive therapy – prognostic criteria