Abstract
Abstract Loss of specificity in the strain A mammary ascites carcinoma subline TA3-Ha appears to be related to decreased immunogenicity rather than to increased immunoresistance. Allogeneic hosts could be induced to reject potentially lethal inocula of TA3-Ha cells by addition of cells from the more specific TA3-St subline or by presensitization with skin grafts from strain A mice. The nonspecific TA3-Ha subline absorbed markedly less activity from H-2 antisera than strain-specific TA3-St cells; however, the absorption capacity of nonspecific TA3-Ha cells for H-2 antisera was noticeably increased by lyophilization, suggesting decreased exposure of H-2 antigens at the cell surface of intact TA3-Ha cells. It is suggested that inaccessibility of histocompatibility antigens on the TA3-Ha cell may be related to presence of a unique sialoglycoprotein at the cell surface in this tumor subline. With the strain-specific TA3-St subline, lyophilization increased H-2k antigenicity while decreasing H-2d activity. The magnitude of these changes, however, was much less than that observed with either H-2d or H-2k antigenicity after lyophilization of TA3-Ha cells.
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