Abstract
During the mid-transmission period of the Ebola virus disease (EVD) outbreak in Sierra Leone, a 19-year-old pregnant woman, who was a petty trader in a health facility in Freetown, noticing no fetal movement for the past 3 days, reported to a health facility. Medical history and laboratory testing showed no abnormalities except that she was positive for sickle cell. She was not known to any surveillance team of having any epidemiological link to EVD case. She was induced with oral medications as well as IV infusion. EVD test showed that the fetus was positive to EVD with a high threshold value of 21, while the woman was negative for EVD with a threshold value of 42. The woman was positive to EVD IgG but negative to EVD IgM by ELISA technique. This is a rare EVD case in the period of medium transmission. We conclude that the woman may have come into contact with a low dose of virus not enough to cause a full blown EVD and that her immune system was able to stop the virus from further replication.
Highlights
Republic of Congo in 1971.1,2 The first major outbreak of Ebola virus disease (EVD) in West Africa was the one witnessed in 2014, which claimed of the last EVD outbreak in West Africa
Sergie et al.[16] protective equipment. The surveillance this was again taken to another laboratory reported a low prevalence of HIV in inditeam was called in to investigate the case. for confirmation and it returned a posi- viduals with sickle cell and attributed this to tive qPCR test of 21.5 threshold
We are aware that the virus replicates faster in newborns than in adults, which may explain the high viral load in the fetus while the mother remains negative
Summary
The safe and dignified burial team the virus could not replicate quickly in her, was called, swabbed the dead baby and the Laboratory results enabling the virus’s immune response sample was transported to the nearest labo- The nurses who the nearest laboratory and it returned posi- low prevalence of viral infections in indiengaged the patient realized a full personal tive to direct qPCR with CT value of 21; viduals with sickle cell. The surveillance this was again taken to another laboratory reported a low prevalence of HIV in inditeam was called in to investigate the case.
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