Abstract
Aluminium (Al) is toxic to the growth of fetuses and sucklings. However, the incorporation of Al into fetuses and sucklings in the periods of gestation and lactation has not been well clarified because Al lacks a suitable isotope for a tracer experiment. In this study, we used 26 Al (a radioisotope of Al with half-life of 716,000 yr) as a tracer, and measured 26 Al incorporation into fetuses and sucklings by accelerator mass spectrometry (AMS). To investigate Al incorporation into fetuses through transplacental passage, 26 Al ( 26 AlCl 3) was subcutaneously injected into pregnant rats on day 15 of gestation. 26 Al was also subcutaneoulsy injected into lactating rats from day 1 to day 20 postpartum. By day 20 of gestation, 0.2% of the 26 Al injected into a pregnant rat had been transferred to the fetuses, and 26 Al was detected in the brain and liver of the fetuses. On day 9 postpartum, high levels of 26 Al were demonstrated in the brain, liver, kidneys and blood of suckling rats. It is concluded that 26 Al subcutaneously injected into pregnant rats and/or lactating rats is incorporated into their offspring through transplacental passage and/or maternal milk.
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