Abstract
The transplacental passage of demeton labeled with radioactive phosphorus (32P) in pregnant CF-1 mice was followed autoradiographically in frozen sections of fetal and placental tissues. The organophosphorus insecticide was injected intraperitoneally on the 14th day of gestation at a dose of 5 mg/kg. Placental tissue, fetal muscle, and osteogenic mesenchyma were heavily labeled within 20 minutes, the radioactivity decreasing with longer periods of treatment. Liver incorporated demeton maximally between one and two hours. The compound appeared to be rapidly metabolized because fetal tissues showed only trace activity after three hours.
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