Abstract
This paper gives the results of a study of the transplacental action of methylcobalamin (MC) on growth of embryonic tissues during organ culture. An organ culture of embryonic mouse kidney tissue, sensitive to the transplacental action of biologically active substances, including vitamins and hormones, and also of chemical carcinogens, was used as the experimental model. /sup 3/H-thymidine was added to the nutrient medium before fixation of the explants. The stimulating effect of MC on growth of mouse kidney tissue in the prenatal period as revealed in this investigation, is said by the authors to be an important mechanism modifying the transplacental action of chemical carcinogens.
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