Abstract
1. Phencyclidine concn in plasma of pregnant and non-pregnant sows and in umbilical cord and neonatal plasma was determined by g.l.c. after a single intramuscular dose of phencyclidine hydrochloride. 2. The rate of elimination of the drug, as determined from plasma phencyclidine concn, was unchanged by pregnancy. 3. Phencyclidine concn in piglet plasma was approx. 10-fold higher than in maternal sow plasma and declined more slowly (t 1/2 about 6 h) than the concn. in adult sows (t 1/2 about 2 h). 4. Studies of phencyclidine uptake by piglet and sow plasma in vitro indicate that the higher concns in piglet plasma are due to a marked affinity of piglet plasma proteins for the drug, although both total protein and albumin concn is lower than in sow plasma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Xenobiotica; the fate of foreign compounds in biological systems
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
