Abstract
Here, we report the fabrication of transparent multichannel vertical nanotube electrode arrays for detecting cellular activity and optically imaging neuronal networks. To fabricate these transparent electrode arrays, position- and morphology-controlled ZnO nanotube arrays consisting of ultrathin nanowalls were grown on transparent graphene layers and coated with Ti/Au metal layers. Using these multichannel arrays, electrophysiological signals were individually recorded from primary mouse hippocampal neurons and recorded distinctive intracellular potential-like signals. Moreover, the transparent electrode array enabled fluorescence imaging of neuron cell bodies and neurite connections. This transparent graphene- and nanotube-based recording device is proposed to greatly increase the versatility of capabilities for investigating neuronal activity through simultaneous recording and imaging of neuron cultures.
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