Abstract
Hydroxyapatite is an essential inorganic component of bone tissue that is important for bone cell biology. In laboratory, bone cells are routinely cultured on glass or plastic plates with lacking of HA. Some commercial plates coated with HA are now available for investigating osteoclast bone resorption. However, the opaque nature of these plates limits further application to investigating bone cell biology. It's impossible to observe real-time interactions between hydroxyapatite and bone cells under microscope. In this study, glasses with HA nano-coatings were prepared by hydrothermal process. These nano-coating platform(NCP) offering a stage to directly image real-time interactions between hydroxyapatite and bone cells. The ease of fabrication and the repeatability of this platform approach could open a host of biomedical imaging applications in bone biology research as well as bone drug development. Different osteocytes were used to detect the biocompatibility and imaging advantages of the platform. Results showed that the platform could simulate the native bone environment and reflected the state of the bone cells accurately.
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