Abstract
Proton-pump inhibitor (PPI) therapy has been relatively ineffective in treating symptoms of troublesome and predominant regurgitation, as opposed to heartburn, in patients with gastroesophageal reflux disease (GERD). These patients are typically referred for antireflux surgery, which is traditionally a Nissen fundoplication. Although this procedure can be highly successful in expert hands, performance has varied widely between surgeons and adverse effects are frequent. Hence, this operation has fallen into relative disfavor. Alternately, transoral fundoplication …
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