Abstract
Background Catheter-based transmyocardial injection offers a minimally invasive method to deliver therapeutics to the heart. It is typically performed under X-ray fluoroscopic guidance, which suffers from poor demarcation of myocardial boundaries and an inability to assess myocardial viability. MRI-guided intramyocardial delivery of therapeutics at 3T offers the potential for more precise targeting of these therapies with superior tissue contrast. Our group has been actively involved with microencapsulated stem cell therapy to improve cell retention and prevent stem cell rejection. However, conventional microencapsulated stem cell products are too large to be administered transmyocardially. We demonstrate here intramyocardial injection of a prototype single stem cell therapeutic into the myocardium of a normal swine using real-time MR guidance and a custom active injection catheter.
Highlights
Catheter-based transmyocardial injection offers a minimally invasive method to deliver therapeutics to the heart
MRI-guided intramyocardial delivery of therapeutics at 3T offers the potential for more precise targeting of these therapies with superior tissue contrast
Our group has been actively involved with microencapsulated stem cell therapy to improve cell retention and prevent stem cell rejection
Summary
Shashank S Hegde1*, Steven Shea, Li Pan, Parag Karmarkar, Julien Barbot, Klaus J Kirchberg, Fijoy Vadakkumpadan, Jeremy Maurer, Judy A Cook, Natalia Trayanova, Meiyappan Solaiyappan, Peter V Johnston, Dara Kraitchman. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013
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