Abstract
A quantitative study of monoamine oxidase (MAO) and catechol- O-methyl transferase (COMT) has been made on homogenates of adult rabbit thoracic aorta. Most of the activity of both enzymes is located in the tunica media. The ratio of adventitia/media distribution of COMT is considerably less than the corresponding ratio for MAO. The specific activities of MAO and COMT change in parallel through the greater part of the transmural profile obtained on 24 μ cryostat sections. The specific activity of COMT drops significantly in sections that include endothelium and subendothelial media, where no decrease in MAO is noted. Subcellular distribution studies indicate the presence of MAO in mitochondrial and microsomal fractions, compared to the predominantly microsomal and cell sap localization of COMT.
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