Abstract
Transmucosal delivery of macromolecules using vaginal electroporation to treat vestibulodynia: A pilot study
Highlights
Vulvodynia is a common multifactorial, heterogeneous, and chronic gynecological disorder that affects a large number of women worldwide
The Visual analogue scale (VAS) was reduced from a baseline of 7.4 (1.2) to a 6.3 post therapy (1.8), and despite the variation not apparently of large extent was statistically significant (p 0.05)
Based on what aforementioned vaginal EP can be defined as an promising technique in the management of VBD
Summary
Vulvodynia is a common multifactorial, heterogeneous, and chronic gynecological disorder that affects a large number of women worldwide. It is estimated that the prevalence rate of vulvodynia is 16% in women aged 18 to 64 years, resulting in constant demand for medical care [1]. The predominant form of vulvodynia, provoked vestibulodynia (VBD), is characterized by burning and cutting pain localized to the vulvar vestibule in response to light touch [2]. Vulvodynia may result from peripheral sensitization in the skin, central sensitization in the spinal cord, or both of them. An inflammatory process in the vulvar skin could release a cascade of cytokines that sensitize the nociceptors resulting in a physical increase in the number of nerves. Provoked vestibulodynia (VBD), is characterized by burning and cutting pain localized to the vulvar vestibule in response to light touch
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