Abstract
Experimental manipulation has revealed the potential for remarkable plasticity in the expression and development of neurotransmitter phenotypic characters (Black and Patterson, 1980; Le Douarin, 1980; Black, 1982). While autonomic neurons, which have been examined in particular detail, may alter a number of transmitter characters, and even acquire new transmitters in culture (for reviews, see Patterson, 1978; Varon and Bunge, 1978), relevance to in vivo events has not been fully determined. Two issues of central interest may be identified: Do neurons or their progenitors normally exhibit phenotypic plasticity during ontogeny in vivo? If they do, does phenotypic plasticity persist into adulthood in the postmitotic neuron?
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