Transmit beam design for tissue harmonic volume imaging of muscular tissues with a row-column array

Abstract

Row-Column-addressed Arrays (RCAs), which have recently become commercially available, transmit along the rows and receive along columns of a 2D array in order to produce 3D volume images with low channel count. Imaging of the inherently three-dimensional, layered, and fibrous structure of muscular tissues in 3D using an RCA can improve evaluations of muscle function and disease compared to conventional 2D cross-sectional imaging, but volume images obtained using an RCA suffer from low lateral spatial resolution, low contrast, and grating lobe artifacts. Tissue harmonic imaging (THI) employs nonlinear acoustic effects to image at twice the transmit frequency, and can yield increased spatial resolution, increased contrast, and decreased artifacts from grating lobes. Here we investigate transmission considerations for THI in muscular tissues using a commercially available RCA (Vermon RC6gV). The parameter space is explored efficiently with frequency domain simulations of the 3D Westervelt equation. Pulse inversion imaging is applied experimentally using both steered plane wave and focused transmits to evaluate THI with an RCA in tissue phantoms and in muscular tissue. Pulse inversion volume images are compared to conventional images in terms of signal-to-noise, contrast, and ability to identify layers and fibrous structures in muscle in 3D. [Work supported by NIH HEAL Initiative R61AT012282.]