Abstract
Transmission of Varicella Vaccine Virus, Japan
Highlights
To the Editor: Varicella-zoster virus (VZV), a human herpesvirus, is the causative agent of varicella and herpes zoster
After receiving oral acyclovir treatment, the boy recovered without systemic complications
To determine whether vOka or a wild-type VZV strain caused the varicella in this boy, we performed PCR to amplify the entire region of gene 62 and determine its sequence, as described previously [4]
Summary
To the Editor: Varicella-zoster virus (VZV), a human herpesvirus, is the causative agent of varicella (chickenpox) and herpes zoster (shingles). Herpes zoster developed in a healthy 3-year-old girl 2 years after she had received the varicella vaccine (lot VZ040; Biken, Osaka, Japan). On day 19 after the girl’s onset of herpes zoster, an enzyme immunoassay (Denka Seiken, Tokyo, Japan) confirmed the presence of VZV-specific immunoglobulin (Ig) G (titer 48.9, well above the detection limit of 2.0) but not IgM.
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