Abstract
The transmission of Creutzfeldt-Jakob disease (CJD) to the patas monkey, Erythrocebus patas, has been accomplished. Clinical neurological disease was first noticed 47 months and 23 days after intracerebral inoculation of infected squirrel monkey brain. The disease progressed slowly and lasted 8 months. Microscopic examination of the brain and spinal cord revealed lesions of status spongiosus and astrogliosis in the cortical gray matter consistent with a diagnosis of experimental CJD. A vacuolating 'spongiform' cytopathological effect was seen in many of the in vitro cultivated brain cells in the outgrowth from explanted brain tissue of this monkey.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
