Transmission of circulating IgG into preovulatory mouse eggs

Abstract

Mice were injected intravenously with radioactively labelled rat IgG or human serum albumin (controls) and their ovaries subsequently investigated by autoradiography at the light and electron microscopical levels. Both of the administered proteins reached the cytoplasm and nuclei of the oocytes at all except the late secondary and early tertiary follicular stages. The entry of the IgG into the eggs was higher than the entry of the albumin.