Abstract
In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origin was transmitted among dogs, we experimentally infected beagles with this influenza virus (H3N2) isolate. The beagles shed virus through nasal excretion, seroconverted, and became ill with severe necrotizing tracheobronchitis and bronchioalveolitis with accompanying clinical signs (e.g., high fever). Consistent with histologic observation of lung lesions, large amounts of avian influenza virus binding receptor (SAalpha 2,3-gal) were identified in canine tracheal, bronchial, and bronchiolar epithelial cells, which suggests potential for direct transmission of avian influenza virus (H3N2) from poultry to dogs. Our data provide evidence that dogs may play a role in interspecies transmission and spread of influenza virus.
Highlights
In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/ Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease
We report interspecies transmission of a complete avian influenza virus (H3N2) to dogs and the emergence of a new canine influenza virus associated with acute respiratory disease in South Korea, where avian influenza viruses (H3N2, H5N1, H6N1, and H9N2) currently circulate or have been previously detected [8]
Nucleotide Sequences Eight gene segments (H3, neuraminidase 2 (N2), PB1, PB2, PA, nucleocapsid protein (NP), M and nonstructural protein (NS)) of each isolated canine influenza virus were sequenced (EU127500, H gene; EU127501, N gene), and homologous sequences were sought in GenBank (Table)
Summary
In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/ Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origin was transmitted among dogs, we experimentally infected beagles with this influenza virus (H3N2) isolate. We report interspecies transmission of a complete avian influenza virus (H3N2) to dogs and the emergence of a new canine influenza virus associated with acute respiratory disease in South Korea, where avian influenza viruses (H3N2, H5N1, H6N1, and H9N2) currently circulate or have been previously detected [8]. We investigated pathogenicity of the isolated virus in experimental dogs and evaluated localization of SAα 2,6-gal and SAα 2,3-gal linkages in upper and lower canine respiratory tracts
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