Abstract
Efficient translocation of specific molecules across cell plasma membrane is crucial for cell viability and drug delivery. However, it remains elusive what molecular properties are necessary for spontaneous translocation and how to transport molecules without such properties. Here, we investigated the effect of transmembrane proteins on the translocation of amphiphilic peptides. Using two different coarse grained models, we consistently demonstrate that transmembrane proteins with a hydrophilic patch enhance the translocation of amphiphilic peptides by their stabilization in the membrane.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
