Abstract
The transmembrane behavior of rich arginine( R) peptide modified gold nanoparticles was studied. The functionalization of the gold nanoparticles was achieved by the conjugation of transmembrane peptide RRRRRRRR(R-8) with peptide CALNN stabilized gold nanoparticle through the standard streptavidin-biotin chemistry. The transmembrane delivery of the model compound, fluorescein, was studied by confocal scanning laser microscope. The result suggests that the R-8 modified gold nanoparticles can be used as an excellent vector for transporting extracellular materials into cells with low cellular cytotoxicity.
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