Abstract
Rearrangements of the chromosome locus 11 band q23 are among the more common cytogenetic abnormalities seen in acute leukaemia. They occur in about 10% of acute lymphoblastic leukaemias, 5% of acute myeloid leukaemias, and 85% of the secondary leukaemias, usually the M4 or M5 subtypes of acute myeloid leukaemia, which develop as a consequence of treatment with topoisomerase II inhibitors.1 Although more than 50 reciprocal chromosomal loci have been described in 11q23 translocations, the most common are t(4;11)(q21;q23), t(9;11)(p22:q23), and t(11;19) (q23;p13).
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