Abstract
Human β defensins (hBDs) are cationic cysteine-rich small peptides and are primarily expressed by epithelial cells. They belong to the human innate immune system and have a broad-spectrum of antibacterial activities on bacteria, fungi, and viruses. It is believed that hBDs directly disrupt bacterial lipid membranes, break the cell membrane, thus to kill the cell. Despite their structural similarities, hBDs have diverse antibacterial activities. In order to understand the antibacterial mechanism of hBDs, a comparative study on hBD type 1 (hBD-1) and type 3 (hBD-3) was conducted in this project, and the translocation free energies of hBDs through model Gram-positive/negative bacterial membranes and red-blood cell membranes (POPC) were predicted.
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