Abstract
Itano was the first to postulate a role for transfer RNA (tRNA) in regulating the rate of translation of hemoglobin messenger RNA (mRNA) (Itano, 1965). A theoretical foundation for such a role was shown when Weisblum et al. (1965) demonstrated that leucine tRNA can be separated into two fractions which insert leucine into different positions in the hemoglobin chains. This work has been extended to show that a similar phenomenon exists for tRNAs carrying serine (Gonano, 1967), arginine (Weisblum et al., 1967) or glutamic acid (Sekiya et al., 1969). Since different species of tRNA can be responsible for inserting an amino acid into different positions in the hemoglobin chains, the presence of a limiting amount of one species might produce a reduced rate of mRNA translation at a given point. Winslow and Ingram have shown, in fact, that the rate of assembly of hemoglobin chains in human bone marrow cells...
Published Version
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