Abstract
Background The Human Immunodeficiency Virus type 1 Tat protein is a major viral transactivator which stimulates the synthesis of full length transcripts by interacting with the 5’end of all nascent viral RNAs. Translation of tat mRNAscan be cap dependent. Nevertheless, in phaseG2/M ribosomes translate tat mRNAs by an alternative initiation processdepending on anlnternal Ribosome Entry Site (IRES). This initiation is auto-stimulated by Tat [1]. Recently, SRp40 and SRp55 proteins were found to promote Gag IRES-dependent translation initiation [2]. Therefore, SR and hnRNP proteins likely play a key role in regulation of both splicing and translation of HIV-1 RNA. As we previously observed a binding of hnRNP H (3), DAZAP1 and various SR proteins in the vicinity of the tat initiation codon(4), we asked whether these proteins can regulate tat mRNA translation.
Highlights
The Human Immunodeficiency Virus type 1 Tat protein is a major viral transactivator which stimulates the synthesis of full length transcripts by interacting with the 5’end of all nascent viral RNAs
In phaseG2/M ribosomes translate tat mRNAs by an alternative initiation processdepending on anlnternal Ribosome Entry Site (IRES)
SR and hnRNP proteins likely play a key role in regulation of both splicing and translation of HIV-1 RNA
Summary
Background The Human Immunodeficiency Virus type 1 Tat protein is a major viral transactivator which stimulates the synthesis of full length transcripts by interacting with the 5’end of all nascent viral RNAs. Translation of tat mRNAscan be cap dependent.
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