Abstract

There has been an exponential growth in the application of AI in health and in pathology. This is resulting in the innovation of deep learning technologies that are specifically aimed at cellular imaging and practical applications that could transform diagnostic pathology. This paper reviews the different approaches to deep learning in pathology, the public grand challenges that have driven this innovation and a range of emerging applications in pathology. The translation of AI into clinical practice will require applications to be embedded seamlessly within digital pathology workflows, driving an integrated approach to diagnostics and providing pathologists with new tools that accelerate workflow and improve diagnostic consistency and reduce errors. The clearance of digital pathology for primary diagnosis in the US by some manufacturers provides the platform on which to deliver practical AI. AI and computational pathology will continue to mature as researchers, clinicians, industry, regulatory organizations and patient advocacy groups work together to innovate and deliver new technologies to health care providers: technologies which are better, faster, cheaper, more precise, and safe.

Highlights

  • Artificial Intelligence (AI) along with its sub-disciplines of Machine Learning (ML) and Deep Learning (DL) are emerging as key technologies in healthcare with the potential to change lives and improve patient outcomes in many areas of medicine

  • The majority of efforts to date have focused on the development of neural network architectures in order to enhance the performance of different computational pathology tasks

  • Generative adversarial networks (GANs) are deep neural network architectures comprised of two networks, opposing one against the other (Figure 2)

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Summary

Translational AI and Deep Learning in Diagnostic Pathology

Life Sciences R&D Hub, Digital and Computational Pathology, Philips, Belfast, United Kingdom. Reviewed by: Fernando Schmitt, University of Porto, Portugal Salvatore Lorenzo Renne, Humanitas Research Hospital, Italy. Specialty section: This article was submitted to Pathology, a section of the journal

Frontiers in Medicine
INTRODUCTION
CT images PET scans
Network Architectures
Generative Adversarial Networks
Unsupervised Learning
Prostate Cancer
Metastasis Detection in Breast Cancer
Genetic Mutation Prediction
Tumor Detection for Molecular Analysis
CHALLENGES WITH COMPUTATIONAL PATHOLOGY AS A DIAGNOSTIC TOOL
Key challenges in diagnostic AI in pathology
Findings
CONCLUSION

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