Abstract
During translation, amino acids are not incorporated into the growing nascent polypeptide chain at the same rates; in fact, distinct amino acid sequences, such as a stretch of three or more consecutive prolines, can cause translation to stop. We discovered that ribosomes stalled on these polyproline stretches are rescued by the translation elongation factor P (EF-P). Homologues of bacterial EF-P exist in archaea and eukaryotes (a/eIF-5A), suggesting that this rescue system is universal.
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